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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/26093/18
    Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo\nEffects of Transporter Inhibition on Hepatobiliary Clearance in Mice
    01-Jan-1970 Research 2018 : July - September
    Marco F Taddio, Linjing Mu, Claudia Keller, Roger Schibli, Stefanie D Kramer

    Physiologically based pharmacokinetic modelling (PBPK) is a powerful tool to predict in vivo pharmacokinetics based on\nphysiological parameters and data from in vivo studies and in vitro assays. In vivo PBPK modelling in laboratory animals by\nnoninvasive imaging could help to improve the in vivo-in vivo translation towards human pharmacokinetics modelling. We\nevaluated the feasibility of PBPKmodellingwith PET data frommice.We used data fromtwo of our PET tracers under development,\n[11C]AM7 and [11C]MT107. PET images suggested hepatobiliary excretion which was reduced after cyclosporine administration.\nWe fitted the time-activity curves of blood, liver, gallbladder/intestine, kidney, and peripheral tissue to a compartment model and\ncompared the resulting pharmacokinetic parameters under control conditions ([11C]AM7

    How to Cite this Article
    CC Compliant Citation: Marco F. Taddio, Linjing Mu, Claudia Keller,\nRoger Schibli, and Stefanie D. Krämer, â??Physiologically Based\nPharmacokinetic Modelling with Dynamic PET Data to Study the In\nVivo Effects of Transporter Inhibition on Hepatobiliary Clearance in\nMice,â? Contrast Media & Molecular Imaging, vol. 2018, Article ID\n5849047, 11 pages, 2018. https://doi.org/10.1155/2018/5849047,\nhttps://creativecommons.org/licenses/by/4.0/.
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